Immediate Release Tablets Of Gemfibrozil Development And Invitro Characterization

Abstract

The aim of the present study is to develop and evaluate the immediate release tablet of Gemfibrozil by direct compression method. The superdisintegrant Poloxamer 188, Cross carmellose sodium and Polyplasdone XL10 were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F6 exhibit highest dissolution using Cross carmellose sodium showed faster drug release 99.22% over the period of 30min while disintegration time of the tablet was showed 35 sec comparison to other formulations of Gemfibrozil. From this study we can conclude that, formulated tablets of Gemfibrozil containing Cross carmellose sodium are better and effective than conventional tablets to meet patient compliance.