Formulation and Invitro Evaluation of Floating Pulsatile Drug Delivery System of Repaglinide

Abstract

The main objective of the present research work was to develop chronomodulated, floating-pulsatile drug delivery system to release the drug in distal small intestine part of the GIT in order to achieve chronotherapeutics release of Repaglinide without releasing the drug during floating, for the treatment of rheumatoid arthritis, osteoarthritis, spondylitis and to improve the patient compliance. A chronodelivery system, based on biological rhythms, is a state-of-the-art technology for drug delivery to increase safety, efficacy and also improves overall drug performance. In this research work preparation of pulsatile drug delivery system was prepared using super disintegrants like Crospovidone, croscarmellose sodium and SSG were selected in the system.  Whereas coated tablets were prepared by using HPMC K100M, and HPMC K200M. All the prepared formulations were analysed for Pre-compression parameters were conducted for all formulations blend and were found to be satisfactory. From the Invitro drug release data of the core tablets it was concluded that the formulation F9 of core tablet containing 15 mg of Sodium Starch glycolate shows immediate release while compared with other super disintegrants. From the drug release data of the press coated tablet it was concluded that the formulation M5F11 maintains lag phase for 5-6 hours and the drug release was bursted at the end of 9 hours. It follows first order release and follows super case II transport mechanism