Formulation and invitro characterization of lamotrigine fast dissolving tablets by solid dispersion technique

Abstract

An antiepileptic drug called lamotrigine is a phenyl triazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. It is a medication of BCS class II with a longer half-life. Lamotrigine solid dispersion with oral disintegrating tablet was created using Xylitol, Sorbitol, and SSG to enhance biological performance. Lamotrigine solid dispersions were created using several carriers at various drug and carrier ratios (1:1, 1:2and1:3). Results of solid Lamotrigine dispersions made using the solvent evaporation method, including solubility, melting point analysis, drug content homogeneity, and in vitro dissolution experiments, were discussed.  Numerous analytical methods, including FT-IR studies, were used for solid-state characterization. The formulation (F6) combining lamotrigine + SSG (1:3) exhibits better results by solvent evaporation method at the end of 60 min with maximum drug release, hence it was chosen as the best formulation in the end by comparing all of the formulations. The Fast-dissolving tablets were created from the optimal formulation employing various disintegrants at various concentrations.  The parameters for pre- and post-compression were examined, and the findings were presented. All findings fall within the allowed range. Using a buffer with a pH of 0.1N, the in vitro drug release of the prepared tablets was carried out. PEG-4000-containing formulation F6C6 demonstrates 99.87% drug release in 20 minutes. First order release kinetics is followed by the improved formulation.