Formulation And In Vitro Characterization Of Nelfinavir Extended-Release Tablets

Abstract

The current work was focused to formulate and evaluate extended release tablets of Nelfinavir. Eudragit RL, Ethyl Cellulose and Carbopol p934 are matrix polymer can be used in formulation of extended release dosage form. Nelfinavir was considered as ideal drug for extended release formulation. The extended release matrix of Nelfinavir were prepared by direct compression method in differ matrix polymers ratio. Pre formulation studies have been performed for the Active Pharmaceutical Ingredient. Drug Excipient compatibility studies have been performed and the tablets have been prepared in eight different formulations with the change in the ratios of polymers. These tablets are evaluated for various parameters including the release of drug by using dissolution studies. Hence the study resulted in the development of Nelfinavir extended release tablets N4 formulation was considered as optimized formulation. The Kinetic treatment of selected formulation N4 showed that the release of drug follows Zero order models.