EFFECT OF ETHANOLIC EXTRACT OF PIPER CUBEBA LINN. FRUITS ON ACTIVITY OF PIOGLITAZONE

Abstract

Herb-drug interaction about Oral antidiabetic drugs is a challenging concept, since the consumption of food and other herbal drugs is not documented in diabetic patients profile. Present work was designed with an objective to investigate any possible effect of herbal drug Piper cubeba Linn. fruits on Pioglitazone-Oral antidiabetic drug. Albino male wistar Rats were made diabetic using Alloxan monohydrate 180 mg/ kg and divided into 4 groups of 6 animals each.Group II, Group-III and Group-IV were administered with Ethanolic extract  of  Piper  cubeba  Linn.  fruits,  EtPCLF  (400  mg/kg),  Pioglitazone  and  EtPCLF  +Pioglitazone  10mg/kg respectively. All the 4 groups were tested with intraperitoneal glucose tolerance test (IPGTT) by administering glucose (2.5%) intraperitoneally and decrease in blood glucose concentration was determined in each group using glucometer. EtPCLF enhanced the activity of Pioglitazone and significantly lowered Blood glucose concentration in EtPCLF + Pioglitazone treated group when compared to Pioglitazone alone treated group. Hence EtPCLF enhances the activity of Pioglitazone.