Importance of advanced topical drug delivery: Emulgel of Nsaids in the treatment of Arthritis and inflammation

Abstract

Topical formulations are having good patients compliance for many chronic diseases due to its better localised

action. Emulgel is one of the most interesting NDDS used topically having characteristics of dual control

release i.e. emulsion as well as gel. Emulgel is a combination of gel and emulsion, emulsion either O/W or

w/O type, which are gelled by mixing with different gelling agents which allows the formulation to stable by

decreasing surface and interfacial tension at the same time increases the viscosity of aqueous phase. In spite of

many advantages of gels a major limitation is to deliver the hydrophobic drugs emulgel is proven potential

formulation to deliver hydrophobic drugs. Emulgel is used topically because of its characteristic dual control

release (i.e.) emulsion as well as gel it demonstrates better drug release as compared to other topical drug

delivery system due to excess of oil bases and lack of insoluble excipients. Emulgel are having major

advantages on novel vesicular systems as well as on conventional systems considering various aspects.

Numerous permeation enhancers can potentiate the effect of decreasing skin barrier resistance on the other hand

promoting solubility of the drug in vehicle is also feasible. The use of emulgels can be considered well for

NSAIDS in the treatment of chronic inflammation and arthritis