Formulation and characterization of β-cyclodextrin Nanosponge of luliconazole for topical delivery
Keywords:
Luliconazole, nanosponges, hydrogel, β-cyclodextrin, dermatomycosis, solubility enhancement, PVP K30Abstract
Objective: Luliconazole is a BCS class-II topical broad spectrum imidazole antifungal agent which is used for the treatment
of superficial dermatomycosis. It has poor aqueous solubility and less dermal availability. To overcome these problems the
luliconazole is loaded into β-cyclodextrin nanosponges and incorporated into hydrogel for topical delivery.
Methods: The nanosponges are formulated using β-cyclodextrin (polymer) and Di-phenyl carbonate (cross linker) in different
molar ratios (1:2, 1:4 and 1:6) by melting method. The drug is loaded by freeze-drying method with and without the addition
of PVP K30. The physical parameters, drug content, in-vitro release studies are performed. The selected best formulation was
loaded into carbopol-934 hydrogel. The physical parameters and in-vitro antifungal activity were performed.
Results: The results of the characterization of the best formulation were obtained 510.5 nm and -14.1 particle size and zeta
potential respectively. The solubility also (0.0476 mg/ml) 14 folds increased when compared pure drug. The formulation
loaded hydrogel exhibited good physical properties and in-vitro drug release after 12hours was found to be 84.78%. The invitro antifungal activity also (14.8mm) increased when compared to marketed cream (9.1mm).
Conclusion:This study revealed that prepared luliconazole loaded hydrogel has a great potential to improve the topical
delivery of drug as compared with conventional cream.
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