Formulation and stastical optimisation of fast dissolving tablets of ambroxol hydrochloride

Abstract

The aim of the present study is to formulate and optimize fast dissolving tablets of Ambroxol hydrochloride using a 23

response surface methodology employing Design Expert-10.0. Sodium starch glycolate and Camphor were selected as

independent variables while disintegration time (sec) and water absorption ratio (%) were considered as responses. The

prepared tablets were evaluated for various evaluation parameters including hardness, thickness, friability, drug content

uniformity, wetting time, water absorption ratio and disintegration time. The prepared optimized fast dissolving tablets

of Ambroxol hydrochloride having above 2 responses-disintegration time(sec) and water absorption ratio of sec and %

.The optimized batch having concentration of sodium starch glycolate and camphor was found within the standard limit

of parameters-disintegration time (sec) and water absorption ratio(%).The direct compression method in this study is

relatively simple and safe and a stable, effective and pleasant tasting fast dissolving tablets, which has a good balance

over disintegration time and water absorption ratio, was formulated.