Formulation and characterization of mucoadhesive microspheres of antidiabetic drug nateglinide

Authors

  • Dr. Kavitha Rajesh Assistant Professor, Department of Wellness, Faculty of Health, Sciences, Male', Maldives National University, Maldives

Keywords:

Nateglinide, Polycarbophil, Mucoadhesive microspheres, Double emulsion solvent evaporation technique.

Abstract

Nateglinide is an anti-diabetic, oral blood-glucose lowering drug of the meglitinide class used in the

management of type-II diabetes mellitus. The present investigation involves formulation and evaluation of

mucoadhesive microspheres with nateglinide as model drug for prolongation of drug release time. An attempt

was made to develop microspheres of nateglinide by double emulsion solvent evaporation technique, with a

view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into

systemic circulation. The mucoadhesive microspheres were formulated by double emulsion solvent

evaporation technique using polycarbophil as polymer, the prepared microspheres were evaluated for Flow

behavior, Compatibility study, Drug Entrapment Efficiency, In-vitro Dissolution, particle shape and size by

Scanning Electron Microscopy and Sieving method.

Dimensions

Published

2021-08-19