Formulation and characterization of mucoadhesive microspheres of antidiabetic drug nateglinide
Keywords:
Nateglinide, Polycarbophil, Mucoadhesive microspheres, Double emulsion solvent evaporation technique.Abstract
Nateglinide is an anti-diabetic, oral blood-glucose lowering drug of the meglitinide class used in the
management of type-II diabetes mellitus. The present investigation involves formulation and evaluation of
mucoadhesive microspheres with nateglinide as model drug for prolongation of drug release time. An attempt
was made to develop microspheres of nateglinide by double emulsion solvent evaporation technique, with a
view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into
systemic circulation. The mucoadhesive microspheres were formulated by double emulsion solvent
evaporation technique using polycarbophil as polymer, the prepared microspheres were evaluated for Flow
behavior, Compatibility study, Drug Entrapment Efficiency, In-vitro Dissolution, particle shape and size by
Scanning Electron Microscopy and Sieving method.
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