Study On Hospital & Clinical Pharmacy Services In Various Hospitals In And Around Madanapalle

Abstract

The aim of this study was to formulate and evaluate the oral tablet formulations of Ibuprofen fast oral

disintegration and increasing the oral palatability by masking the bitter taste of the drug component. As the

drug imparts a bitter taste it is optimised in aspect of sweeteners and flavours also obtained by coating

adifferent polymer. The plan of work comprises of characterisation of API with pre formulation

studiessuch as Angle of Repose, Bulk Density, Tapped Density, Compressibility Index, Hausner’s Ratio,

Particle Size Distribution, Drug excipient comparability study, Solubility study. This is followed by taste

masking achieved by addition of sweeteners and flavours and coating with hydrophobic additives. The

drug component then processed with the developmental parameters such as Direct compression, Dry

granulation and Wet granulation. This part of the formulation is further scaled to identification and

optimization of the disintegrants in the formulation. Once the stability parameters of the formulation are

accessed, it is then proceeded with analytical process conducted in order to select and evaluate the best

formulation among them.