Influence of dissolution media and pH on the dissolution characteristics of diclofenac sodium pure drug

Abstract

The present study was performed to illustrate the effect of different dissolution media and PH on dissolution profile of diclofenac
sodium sustained release of granules. Diclofenac sodium has analgesic antipyretic and anti-inflammatory activities. It is a potent
relatively non selective Cyclooxygenase inhibitor. It is absorbed rapidly and completely after oral administration; peak
concentration in plasma reached with-in 2-3 hours. The drug extensively binds to plasma protein (99%) and its half-life in plasmais1-
2hours. Diclofenac sodium extended release are prescribed for long symptomatic treatment of Rheumatoid arthritis, Osteo-arthritis.
The PH buffer selection bases on exposer of drug from stomach to intestine and ensure the impact of PH changes on dissolution and
release of drug substance for absorption. Dissolution is used to show the release of drug from the tablet is close to 100%. The
dissolution behavior of drug in a particular media permits the selection of right dissolution medium which gives in-vivo and in-vitro
correlation. Based on the ingredients present in dissolution, it is possible to formulate a dosage form with those ingredients to
improve dissolution