Development and characterization of glime pride controlled release osmotic pump tablets

Abstract

The current research involves the development of osmotic pump (CPOP) tablets of Glimepride for the treatment of type 2
diabetes. Core tablets were prepared by direct compression method using hydroxyl propyl methyl cellulose (HPMC), Eudragit,
Sodium Alginate, potassium chloride as osmogen, MCC as diluents and other additives. The prepared tablets were evaluated for
FTIR pre compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy
study. The optimized formulation F4 showed 95.27% at the end of 8 hrs with zero order drug release. Optimized formulation did
not show any significant change on the pH and agitation intensity, but it depends on osmotic pressure of dissolution media
indicated that mechanism of drug release was due to osmotic pressure. stability study at 40±2ºC/75±5% RH for three months on
the F4 formulation indicated that there was no significant change weight variation, % friability, drug content and in vitro drug
release.