Excel College of Pharmacy, Komarapalayam, Namakkal (DT) – 637303, India

Abstract

The Present work at investigating different polymers like Xanthan Gum, Guar Gum, Karaya Gum is an attempt to formulate sustained release matrix tablets containing Methylphenidate. Methylphenidate drug has short half -life makes the development of sustained release forms extremely advantageous. The standard curve of Methylphenidate was prepared in 01 N HCL and 6.8 Phosphate buffer at 258nm. The Nine Formulations were developed by the direct compression method. The in vitro drug release studies were carried out using USP type II apparatus i.e Paddle type. All the pre-compression and post compression parameters are within the limits as
IP. The in vitro drug release F4 formulation showed good drug release i.e 99.92 %. The F4 formulation was consider as optimized Formulation.