Formulation and evaluation of herbal gel containing biophytum sensitivum for the treatment of wound healing

Abstract

Non curative wounds are one of the major problems often encountered in health care system. The resumption of interest to use of Traditional System of Medicine especially plant-based medicines is rapidly growing. Herbs are more potent healers and promote the repair mechanisms in a scientific way without causing any side effects. Biophytum sensitivum is used as traditional medicine to cure variety of diseases. The plant Biophytum sensitivum is also useful in the management of wound healing. Gels are a more recent class of dosage forms that are made by trapping a large volume of aqueous or hydro alcoholic liquid in a network of colloidal solid particles. In comparison to ointments and creams, gel formulations typically include quicker drug release. These are superior in terms of patient acceptability and ease of use. In this study we are going to prepare herbal gel containing biophytum sensitivum for the treatment of wound healing. The plant is collected from Calicut district, Kerala, India. The plant material was identified and authenticated from Botanical survey of India, southern regional centre, Coimbatore, Tamilnadu. Plant extract were taken by cold maceration technique using ethanol. After the preformulation studies Gel was formulated as per the procedure. Then evaluation test like homogeneity, Ph, drug content, viscosity, spreadability, extrudability, washability, in-vitro diffusion study and anti-bacterial activity was carried out after the formulation. From these formulations F5 (95.65±0.42) F6 (96.72±0.31) was selected as best formulation based on the in-vitro release and it was incorporated into a gel by using Carbopol 940 as a polymer.