Formulation, development and invitro evaluation of sustained release matrix tablets of capecitabine

Authors

  • G. Sowmya Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal, Hyderabad, Telangana-501510, India.
  • P. Nagaharitha Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal, Hyderabad, Telangana-501510, India.
  • Venu Madhav Katla Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal, Hyderabad, Telangana-501510, India.

Keywords:

Capecitabine, HPMC-K 100 M, Sodium Carboxy Methyl Cellulose, Grewia gum, Almond gum, Sustained release system and Direct compression method

Abstract

The aim of the present study was to develop sustained release formulation of Capecitabine to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC-K 100M, Sodium Carboxy Methyl Cellulose, Grewia gum, Almond gum were employed as polymers. The tablets were prepared by direct compression method. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (C5) showed better and desired drug release pattern i.e., 99.9% in 12 hours. It contains the HPMC-K 100 M 1:1 as sustained release material. It followed peppas release kinetics mechanism.

 

Dimensions

Published

2022-10-20

Issue

Vol. 12 No. 4 (2022): 2022 Volume -12 - Issue 4

Section

Articles
Copyright & Licensing
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