Formulation and evaluation of Miconazole nitrate nanoparticle for topical delivery

Abstract

Miconazole nitrate (MN) is a broad-spectrum antifungal agent of the imidazole group. The drug is primarily used as

a topical treatment for cutaneous mycoses11; poor dissolution and lack of absorption make it a poor candidate for

oral administration. However, MN can be used as a systemic antifungal agent when amphotericin B or ketoconazole

is either ineffective or contraindicated. MN’s poor skinpenetration capability presents a problem in the treatment of

cutaneous diseases by topical application. Nanoparticle ointment has been prepared as the nanoparticle for the

topical delivery. The present study intends to carry out Formulation and Evaluation of Miconazole Nitrate loaded

Chitosan Nanoparticle formulation and to compare with the marketed formulation. In this work, the nanoparticles

were prepared by Ionic gelation method. The optimized nanoparticles were characterized by using different

parameter such as FTIR, SEM, entrapment efficiency, drug release study. The antifungal activity of the MN NPs

was evaluated for 3 different formulations which all showed good results. Further by using the formulationF3 -of

MN NPs, the nanoparticle Ointment was formulated and evaluated for appearance, viscosity, pH, Spreadability, in

vitro release, and its antifungal activity was carried out. All showed good results. The formulated Ointment showed

good zone of inhibition. And finally the formulated ointmentwas compared for its antifungal activity with a

marketed formulation, which showed better antifungal activity than the marketed formulation.