Formulation, development and evaluation for combination of lumefantrine and artemether tablets for effective drug treatment of malaria

Abstract

Aim

To develop various concentrations of excipient formulations and evaluation for combination of two anti- malarial drugs.

Materials and methods

The Lumefantrine and Artemether combination drug-excipients interactions evaluated by pre and post formulation parameters.

FTIR by wet granulation method using different concentration of excipients.

Results and discussions

FT-IR clearly indicates that there are no excipients interactions. The pre-formulations showed the values were within the standard

limit and post-formulations (LUA 1, LUA 2, LUA 3, LUA 4 and LUA 5) were evaluated for various parameters like weight

variation, thickness, hardness, friability, drug content, disintegration and dissolution test. The optimized formulation LUA 4 was

found weight variation (mg) 240±0.55, thickness (mm) 3.17±0.09, hardness (n) 74±1.8, friability 0.5%, drug content 96.33% and

disintegration time is 1min respectively. The dissolution profile of the optimized formulation LUA 4 tablets revealed that

artemether and lumefantrine were released more than 86.75% within 120 mins, 87.60% within 45 mins.The combination of

artemether and lumefantrine tablet optimized all batch were of satisfactory stability.

Conclusion

The combination of artemether and Lumefantrine tablet can be considered for treatment of malaria.