Formulation and evaluation of Baricitinib Buccoadhessive tablets

Authors

Zareena Begum
editorijipsr@gmail.com
Department of Pharmaceutics, Deccan School of Pharmacy, Osmania University, Hyderabad, Telangana, India
S. Shahidullah Department of Pharmaceutics, Deccan School of Pharmacy, Osmania University, Hyderabad, Telangana, India

Baricitinib, Bioadesive buccal tablet in vitro drug release, Bio adhesion strength.

Baricitinib is used to treat rheumatoid arthritis. It helps decrease pain, tenderness, and swelling in the joints. The main objective

of the study was to formulate and evaluate bioadhesive buccal tablets Baricitinib. Bioadhesive buccal tablets were prepared by

direct compression method using bioadhesive polymers like Carbopol, Sodium CMC, Sodium alginate and Hydroxy propyl

methyl cellulose K4M in different ratios. The physicochemical compatibility of drug and polymers was studied by FT-IR

spectroscopy. Prepared tablets were evaluated for in vitro drug release,bioadhesion strength, swelling index, moisture

absorbance, surface pH. Among the prepared formulation containing Sodium alginate (Fc2)was found to be best formulation

which showed the higher bioadhesive strength of 2.68±0.03 N (peak detachement force) and 0.95±0.08 mJ (work of adhesion).

Dimensions