Formulation and evaluation of sustained released matrix tablets of losartn potassium

Authors

  • Dr G. Subba Rao St. Xavier Institute of Pharmacy, Deenapur, Phirangipuram, Guntur, India
  • Balijepalli Siva Prasad St. Xavier Institute of Pharmacy, Deenapur, Phirangipuram, Guntur, India

Keywords:

Losartan potassium, HPMC K100M, Ethyl cellulose, Xanthan Gum, Wet granulation method.

Abstract

The basic goal of therapy is achieve a steady state blood or tissue levels that is therapeutically effective and non-toxic for an extended

period of time. Sustained release drug delivery systems with aim the study of improved patient compliance, better therapeutic efficacy,

less side effects and reduced dosage regimen with less toxicity for treatment for many acute and chronic diseases.Anti hypertensive

drugs are used in the treatment of hypertension. Losartan potassium has been demonstrated to be superior to previous peptide receptor

antagonists and angiotensin converting enzyme (ACE) inhibitors because of its enhanced specificity, selectivity and tolerability. Matrix

tablets are very useful in the field of healthcare for sustained release dosage regimen. Keeping this in view, the present investigation has

been aimed at designing suitable sustained release matrix tablets using polymers like HPMC K100M, Ethyl cellulose, Xanthan Gum by

wet granulation method.

Dimensions

Published

2020-08-13

Issue

Vol. 10 No. 3 (2020): 2020 Volume -10 - Issue 3

Section

Articles
Copyright & Licensing
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