Preparation, Characterization and Evaluation of Pregabalin Microspheres

Abstract

In the present work, Microspheres of Pregabalin using PLGA, Ethyl cellulose and HPMC K4M as polymers were

formulated to deliver pregabalin via oral route. The results of this investigation indicate that solvent evaporation

method can be successfully employed to fabricate pregabalin microspheres. In this work an effort was made to

formulate microsphere of pregabalin by using different polymers. Prepared formulations are evaluated for bulk

density, tapped density, precent mucoadhesion, Percent compressibility, hausners ration, percentage yield, size and

interaction study by Differential scanning calorimeter and in vitro drug release. Formulation which passed all the

evaluation parameters was considered as best formulation of Pregabalin. The present study conclusively that

pregabalin microsphere could be prepared successfully and formulation E5 was shows satisfactory result.