Formulation and evaluation of clopidogrel bisulphate fast dissolving tablets  by novel hole technology

Authors

MD. Rafi Shaik
editorijipsr@gmail.com
Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Sanga Reddy, Hyderabad, Telangana, India.
Naga Manasa.G Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Sanga Reddy, Hyderabad, Telangana, India.
Manjula.G Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Sanga Reddy, Hyderabad, Telangana, India.
Urmila.G Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Sanga Reddy, Hyderabad, Telangana, India.
Anusha.G Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Sanga Reddy, Hyderabad, Telangana, India.

Clopidogrel bisulfate; Vigna Radiata; Novel hole technology; Primo gel; Carbose; Kollidone; In - Vitro Dissolution studies.

The present objective of this research has formulate a Clopidogrel bisulfate fast dissolving tablets by novel

hole technology. Clopidogrel bisulfate is an antiplatelet medication used to reduce the risk of heart disease and

stroke in those at high risk. Basically Clopidogrel is a BCS Class-II type drug, the solubility of drug is low and it is

enhanced by solid dispersion and physical mixture methods by using natural solubility enhancer which is processed

and prepared by Vigna Radiata (Moong bean). The solubility of drug is enhanced by Solvent evaporation method

with a Drug: Carrier ratio of 1:3, from this Solid dispersion equivalent weight to dose of drug is calculated and

formulated fast dissolving tablets by using different super disintegrates. Different tests like pre and post compression

parameters have been performed to evaluate prepared formulations. This quick disintegration of tablets is

additionally influenced by the formation of latest absolute space. With In-Vitro dissolution studies the best

formulation is optimized.

Dimensions