Formulation and invitro evaluation of diltiazem hydrochloride tablets for buccal drug delivery system by using various polymers

Abstract

Diltiazem hydrochloride is a calcium channel blocker used to treat high blood pressure, angina, and certain heart

arrhythmias. It may also be used in hyperthyroidism if beta blockers cannot be used. . The aim of the present study

was to develop buccal formulation of Diltiazem hydrochloride to maintain constant therapeutic levels of the drug for

over 12 hrs. Methocel K15M, Methocel K100M and Locust bean gum were employed as polymers. Diltiazem

hydrochloride dose was fixed as 60 mg. Total weight of the tablet was considered as 300 mg. Polymers were used

in the concentration of 30 mg, 45mg and 60 mg concentration. All the formulations were passed various

physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution

studies it was evident that the formulation (F2) showed better and desired drug release pattern i.e.,97.83 % in 12

hours. It followed zero order release kinetics mechanism.