Optimization and characterization of isoniazid nanoparticles for tubercular management

Abstract

Pulmonary drug delivery has been attractive for both local and systemic drug delivery as a non-invasive route that

provides a large surface area, thin epithelial barrier, high blood flow and the avoidance of first-pass metabolism.

Tuberculosis (TB) is a disease caused by bacteria that are spread from person to person through the air.

Biodegradable Nanoparticles were effective drug delivery systems. For this various polymers have been used in drug

delivery as they effectively deliver the encapsulated drug to a target site and thus enhance the therapeutic benefit and

minimizing the side effect. Nanoparticles are better than liposome’s in tissue targeting in increasing stability of drugs

and posses useful controlled release properties. And hence only in this study the main aim is to formulate and

evaluate solid lipid nanoparticles containing Isoniazid by using solvent evaporation method. But among the two

formulation it was concluded that Solvent evaporation method followed by ultrasonication was an optimized

technique for the preparation of SLN nanoparticle, which lead to better results like high entrapment efficiency, good

percentage yield, high drug content and Span 80 was a better choice of surfactant to reduce the particle size and leads

to uniform distribution of SLN in its phase.