Formulation and evaluation of colon ivermectin immediate release tablets by using natural polymers

Abstract

n the present study it has been aimed at developing pH sensitive tablets of Ivermectin for local action in

proximal colon, with a view of minimizing the drug release in the physiological environment of stomach and

small intestine and to ensure maximum drug release in the physiological environment of proximal colon with an

improved patient compliance, least side effects, better drug therapy and all aspects of an ideal drug delivery

system. In present work attempt was made to formulate and evaluate colon tablets of ivermectin. Attempts were

made to achieve immediate drug release from the dosage form. Twenty seven formulations (F1-F27) were

prepared by direct compression method using 33 Response surface method where 33 indicates 3 variables and 3

levels of natural superdisintegrants like Gellan Gum, Locust bean Gum and Fenugreek seed Gum (low, middle

and high concentrations) by using Design of experiment software. In the Preformulation properties was carried

out and the values obtained were within the range. And FTIR studies results revealed that there was no

incompatibility between drug and excipients. Thus, colon Tablets were formulated by varying proportions of

natural superdisintegrants by direct compression method and all formulations were coated by Eudragit RS 100

coating solution which is a pH sensitive polymer to prevent drug release in stomach and intestine. Entire drug

will release in proximal part of colon.