Gastro retentive drug delivery systems: a review

Authors

  • Prof. P. Shashikala Department of Pharmacy, University College of Technology, Osmania University, Hyderabad- 500007
  • Ganji Navya Sri Department of Pharmacy, University College of Technology, Osmania University, Hyderabad- 500007

Keywords:

Bioavailability; Gastrorentive drug delivery systems (GRDDS); In vitro drug release; Hydrocolloids plasma concentration; Polymers; Therapeutic effect.

Abstract

In recent years, many efforts have been made in order to improve drug bioavailability after oral administration.

Gastroretentive drug-delivery systems (GRDDS) provide a mean for controlled release of compounds that are

absorbed by active transport in the upper intestine. They have the potential to prolong the gastric retenti on time

and provide controlled/sustained release of a drug at the absorption site, thereby improving the bioavailability.

Several approaches are used to increase the gastric residence time, namely bioadhesive or mucoadhesive

systems, expandable systems, high-density systems, floating systems, superporous hydrogels and magnetic

systems. The present review highlights some of the drugs that can benefit from gastroretentive strategies, such

as the factors that influence gastric retention time and the mechanism of action of gastroretentive systems, as

well as their classification into single and multiple unit systems. In the future, it is expected that they will

become of significance in drug therapies.

 

 

Dimensions

Published

2017-01-11

Issue

Vol. 7 No. 1 (2017): 2017 Volume -7 - Issue 1

Section

Articles
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