UV spectroscopic analytical method development and validation of Lurasidone in bulk and tablet dosage form

Authors

  • G. Jaya Syamala Sri Siddhartha Pharmacy College , Nuzvid,Ammavari thota, Andhra Pradesh -521 201,India.
  • V. Naresh Sri Siddhartha Pharmacy College , Nuzvid,Ammavari thota, Andhra Pradesh -521 201,India.
  • M. Kishore Babu Sri Siddhartha Pharmacy College , Nuzvid,Ammavari thota, Andhra Pradesh -521 201,India.

Keywords:

Lurasidone, Limit of Detection, Limit of Quantification, Method development and validation

Abstract

A Simple, accurate, rapid, sensitive and precise UV Spectrophotometric method has been developed for estimation of

Lurasidone in tablet dosage form using UV detector, with a mobile phase consisting of acetone and water 70:30(v/v)

was used and the effluents were monitored at 324 nm. The Proposed study describes a new UV–Spectrophotometric

method development and validation of Lurasidone using simple mobile phase. The method gives good correlation

coefficient with in a short analysis time. The method was validated and found to be simple, sensitive, accurate and

precise. Percentage recovery shows that the method is free from interference of excipients used in formulation.

Therefore, the proposed method can be used for routine analysis of Lurasidone in tablet dosage form.

Dimensions

Published

2019-12-09